Defining a stimuli-response relationship in compensatory lung growth following major resection
نویسندگان
چکیده
منابع مشابه
Defining a stimuli-response relationship in compensatory lung growth following major resection.
Major lung resection is a robust model that mimics the consequences of loss-of-functioning lung units. We previously observed in adult canines, following 42% and 58% lung resection, a critical threshold of stimuli intensity for the initiation of compensatory lung growth. To define the range and limits of this stimuli-response relationship, we performed morphometric analysis on the remaining lob...
متن کاملPerfusion-related stimuli for compensatory lung growth following pneumonectomy.
Following pneumonectomy (PNX), two separate mechanical forces act on the remaining lung: parenchymal stress caused by lung expansion, and microvascular distension and shear caused by increased perfusion. We previously showed that parenchymal stress and strain explain approximately one-half of overall compensation; the remainder was presumptively attributed to perfusion-related factors. In this ...
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Regeneration of gas exchange area by induction of neoalveolarization would greatly improve therapeutic options in destructive pulmonary diseases. Unilateral pneumonectomy is an established model to remove defined portions of gas exchange area and study mechanisms of compensatory lung growth. We addressed the question whether new alveoli are added to the residual lung after pneumonectomy in mice...
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Regeneration of the gas exchange area by induction of neoalveolarisation would greatly improve therapeutic options in destructive pulmonary diseases. Unilateral pneumonectomy is an established model to remove defined portions of gas exchange area and study mechanisms of compensatory lung growth. The question of whether new alveoli are added to the residual lung after pneumonectomy in mice was a...
متن کاملPredictors of exercise oxygen desaturation following major lung resection.
OBJECTIVE To identify predictors of postoperative exercise oxygen desaturation (EOD) in patients submitted to lobectomy or pneumonectomy for lung carcinoma. PATIENTS AND METHODS A consecutive series of 227 patients with non-small cell lung cancer submitted to lobectomy or pneumonectomy from January 2000 through October 2002 were prospectively analyzed. Maximal stair-climbing tests were perfor...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2014
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.01291.2013